The 2005 International Society of Urological Pathology ( ISUP ) Consensus Conference on Glea - son Grading of Prostatic Carcinoma
نویسنده
چکیده
Expert’s summary: After the international WHO sponsored consensus meeting in Stockholm 2004, ‘‘International Consultation on Predictors of Patient Outcome in Prostate Cancer’’ [1,2], the International Society of Urological Pathology (ISUP) identified a need for an additional analysis of the Gleason system with a greater representation from the urological pathology community. More than 70 international leading pathologists in the field of Gleason grading participated in a consensus conference to achieve common guidelines for optimal grading of prostatic carcinoma in biopsies and prostatectomy specimens and how to classify newly described variants of adenocarcinoma of the prostate. Consensus was defined as when at least two thirds of the participants agreed and in most cases it was not a problem to easily achieve this goal. The panel discussed the previous recommendations [3,4] and what modifications were needed to be implemented: First they agreed upon always use low-magnification (4 or 10 ) before eventually use 20 to verify the grade. A ‘‘2005 ISUP Modified Gleason System’’ was presented in which Patterns 1 to 5 were clearly described. Differences in the interpretation of biopsies and prostatectomy specimens were indicated. Overall, the recommendations follow a trend towards the use of higher grades than before and it is clearly defined how to classify rare forms of prostatic carcinoma. Smallcell carcinoma should not be graded according to the Gleason system.
منابع مشابه
Words of wisdom. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.
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